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MINIMUM LETHAL DOSE

CHAPTER 6 PHARMACY AND TOXICOLOGY As you advance in rate, you will become more and more  involved  in  the  administration  of  medicines. Although  drugs  and  their  dosages  are  prescribed  by medical officers and other authorized prescribers, you, as   the   Hospital   Corpsman,   are   involved   in   their administration.    It is necessary for you to learn drug sources,   composition,   methods   of   preparation   and administration,   and   physiologic   and   toxicologic action. This chapter covers pharmacology, toxicology, medication calculations, pharmaceutical preparations, and prescriptions. PHARMACOLOGY LEARNING  OBJECTIVE: Recall   the s u b s c i e n c e s   o f   p h a r m a c o l o g y,   d r u g standards,   medication   administration methods, and factors that affect dosage. Pharmacology  is  the  science  that  deals  with  the origin, nature, chemistry, effects, and uses of drugs. The  subsciences  of  pharmacology  and  their  specific areas of concentration are as follows: ·   PHARMACOGNOSY—the    branch    of pharmacology   that   deals   with   biological, biochemical, and economic features of natural drugs and their constituents. ·   PHARMACY—the  branch  of  pharmacology that deals with the preparation, dispensing, and proper use of drugs. ·   POSOLOGY—the science of dosages. ·   PHARMACODYNAMICS—the study of drug action on living organisms. ·   PHARMACOTHERAPEUTICS—the  study of the uses of drugs in the treatment of disease. ·   TOXICOLOGY—the  study  of  poisons,  their actions, their detection, and the treatment of the conditions produced by them. The science of treating disease by any method that will relieve pain, cure disease, or prolong life is called therapeutics.  Therapeutics does not deal solely with giving  or  taking  medicine.    This  field  also  includes many other methods, such as radiological treatment, diathermy, and hydrotherapy. DRUG STANDARDS T h e    t e x t s    d e a l i n g    w i t h    p h a r m a c e u t i c a l preparations include the  United States Pharmacopeia and  National  Formulary  (USP-NF),  which  provides standards  for  drugs  of  therapeutic  usefulness  and pharmaceutical necessity.  Inclusion of drugs into this compendium is based on therapeutic effectiveness and popularity. The  USP-NF  provides  tests  for  drug identity, quality, strength, and purity. Drug Facts and Comparisons  and the  Physicians’ Desk   Reference   (PDR)   have   multiple   indexes   of commercially   available   drugs. Both   are   used   as advertising outlets for various drug manufacturers.  A comprehensive  description  of  each  pharmaceutical preparation  (including  composition,  action  and  use, administration   and   dosage,   precautions   and   side effects,  dosage  forms  available,  and  the  common (generic) drug names) is provided in both publications. These  two  publications  are  used  as  references  for in-depth  information  on  pharmaceutical  products  by healthcare providers and pharmacy personnel. Remington: The   Science   and   Practice   of Pharmacy    is   probably   the   most   widely   used text/reference in American pharmacies.  It contains all areas  relevant  to  the  art/science  of  pharmacy.     The Pharmacological   Basis   of   Therapeutics   (Goodman and   Gilman)   is   a   textbook   of   pharmacology, toxicology, and therapeutics.   This work is known as the “blue bible” of pharmacology. MEDICATION ADMINISTRATION The   quantity   and   frequency   of   a   drug’s administration to a patient depend on several factors, as  does  the  method  of  that  medication’s  administra- tion.   This   section   will   cover   some   of   the   factors affecting   dosage   calculations   and   methods   of administration. 6-1

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