Toxic Compounds

TOXIC COMPOUNDS DOE-HDBK-1015/2-93 Hazards of Chemicals and Gases CH-05 Rev. 0 Page 12 The absence of a substance from the list does not necessarily indicate that a substance is not toxic. Some hazardous substances may not qualify for the list because the dose that causes the toxic effect is not known. Other chemicals associated with skin sensitization and carcinogenicity (ability to cause cancer) may be omitted from the list, because these effects have not been reproduced in experimental animals or because the human data is not definitive. It is not the purpose of the list to quantify the hazard by way of the toxic concentration or dose that is presented with each of the substances listed. Hazard evaluation involves far more than the recognition of a toxic substance and a knowledge of its relative toxic potency. It involves a measurement of the quantity that is available for absorption by the user, the amount of time that is available for absorption, the frequency with which the exposure occurs, the physical form of the substances, and the presence of other substances, additives, or contaminants (toxic or non-toxic). The purpose of the Material Safety Data Sheet (MSDS) is to ensure the individuals working with chemicals and in the vicinity of chemicals have specific information on these chemicals. This form identifies the chemical by its technical and common name and lists the physical/chemical characteristics and fire, explosion, and reactivity hazards. The second page specifies health hazards and recommends first aid procedures. The safe handling and control measures are also supplied. The MSDS is a very helpful document, and personnel working around chemicals should make it a practice to review these sheets frequently for their own safety. Figures 2 and 3 are copies of the MSDS. The Code of Federal Regulations recommends that the hazards of all chemicals produced and imported be evaluated and the information concerning the hazards be transmitted to the employers and employees. The MSDS, labels on containers, and employee training should be part of a comprehensive hazards communication program.